LANGUAGE, PEDAGOGY AND CULTURAL DIVERSITY. Policy and practice in the Essay

LANGUAGE, PEDAGOGY AND CULTURAL DIVERSITY. Policy and practice in the education of bilingual children - Essay Example hildren through formulation of teaching strategies that are effective in the improvement of academic competency of bilingual students’ as well as analysis of the policies that support bilingual education. The observed school is located in Tower Hamlets in East London. The learning environment in the school is very approachable and welcoming. The observed year one classroom has 30 pupils aged five years with 10 bilingual learners from Mexico, Somalia, Poland, Bangladesh, Brazil and France, making for a widely diverse language and cultural environment. According to Ofsted, the performance of the school is good in terms of pupil achievement, behaviour, quality of teaching, quality of the curriculum pupil’s welfare, health and safety as well as leadership and management. The performance of bilingual pupils’ has improved steadily as they have achieved comprehension that is near that of mainstream children. To improve the performance, it is recommended that pupils be given work that challenges them and matches their level of ability (Ofsted, 2013). Cummins’ 1986 empowerment theory analysis the learning trends of bilingual students’ exploring how status relations and power difference, minority language instruction, interdependence hypothesis, community and school liaison and power and status relationships impacts the school performance of minority groups. Cummins (1986) influence on teaching strategies and policy of bilingual education is arguably very effective in focusing on the education of the bilingual students in a holistic view as opposed to Conteh’s (2009) framework, that extensively focuses on integration of parents and the community. Cummins’ framework enhances the design of intervention to ensure the potential of revising the underachievement of most bilingual pupils’ by encouraging community and parent’s participation as well as collaboration of teachers in pedagogy (Delgado-Gaitan, 1991). According to Cummins, the aim of empowerment is

Critically evaluate Karl Barth's theology of religion and work Essay

Critically evaluate Karl Barth's theology of religion and work - Essay Example Barth work resulted to great effect on how the society interprets and apply Christian teachings. The unpopular and radical approach of Barthian theological thinking about work and Sabbath earned him great criticisms from the mainstream society but his work remains an important component of the current theological scholars and knowledge about Christianity faith. Barth claims that work or human labor is solely utilitarian intended to keep us alive. In this regard, he emphasizes on the importance of observing Sabbath, in order for man to resist the temptation of worshipping work at the expense of serving God (Hughes, 2007). In Barth ideology of Sabbath, the command to rest does not validate man to work for the remaining days of the week. He argues that Sabbath should take precedence of all other activities that man does for the service of God, so that He can reveal His purpose for him. Therefore, Sabbath day according to Barth (2009) gives the meaning and direction of man’s activ ities for the rest of his working days in the week. During Sabbath, man should not consider it as leisure or passive time but rather a day to join God in celebrating His Creation (Barth, 2009). Work or active life is not entirely, what God requires from man, but an activity that man does for survival (Barth, 2009). In this case, Barth argues that Jesus Christ called his disciples to abandon their work and follow him in his ministry but not join work. From his arguments, it is not necessary for man to work because it is worldly and cannot lead to salvation. I disagree with Barth’s opinion on work and Sabbath. When God was creating the universe, all Creations were made in six days and on the seventh day, He rested (Alister, 1999). In this case, God did not rest and then proceed to the work of creation. Though man’s activities do not add up to God’s creations, his actions have a profound effect on the entire universe and its inhabitants. God created man to be the m aster of the universe and its creations, and to fulfill the purpose, man must work not only for his own survival, but for the sake of other creations (Alister, 1999). In poor and underprivileged societies, rest days are liability to such people who struggle hard to afford even a single meal in a day. To such people, taking a break from work in Sabbath amounts to starvation, psychological suffering including anxiety, self-humiliation and depression. Thus, considering economic and social status of people, Barth idea of work and Sabbath is a luxury only the rich can afford. A true Sabbath should result after six days of working earnestly, without deceit or oppression, so that all people regardless of their economic status can fellowship with God and celebrate His Creation. 2. Critically evaluate an issue affecting employers or employees in relation to religious faith and practice Different religions have distinct practices that they instill on their followers and believers. These pract ices normally dictate their daily activities such as mode of dressing, nutrition, duties and responsibilities, health, ways of praying among other behaviors. Alister ( 1999) noted that strict observation of these practices determine the commitment of the believers and more importantly, their desire to attain the highest form of spiritual purity dictated by the teachings of the respective religious denomination. Many religious teachings from diverse backgrounds contain punitive measures meted on followers who fail to comply with the said practices. The punishments are normally carried out by the leaders and/or, adherents of the particular religious grouping on the errant followers (Alister, 1999).

Haematopoiesis Located In Bone Marrow Section Biology Essay

Haematopoiesis Located In Bone Marrow Section Biology Essay Haemopoiesis also known as haematopoiesis located in bone marrow section of an adults and lymphatic tissue is the process of production of blood cells and platelets which continues throughout life, replacing aged cells which are removed from the circulation by which immature precursor cells expand to mature blood cells. This process thesis and how it works is known as monophyletic theory. The cellular blood components are precursor to haematopoietic stem cells (HSC) that forms blood cells and immune cells. Blood cells (BC) are significant in maintenance of immune system in all types of cells in the body which prompt the BC to constantly maintain self renewal. Haemapoiesis stem cells therefore can proliferate, differentiate and even undergo cell death called apoptosis in various types of specialized cells in the body. The morphology and growth of BC sometimes occurs outside the bone marrow cells called extramedullary haemopoiesis. This is abnormal condition associated with Myelofibrosis caused by disorder in the bone marrow due to abnormal stem cell results or replacement by collagenous connective tissues. The sources of HSC are bone marrow, peripheral blood, umbilical cord blood, Foetal Hematopoietic, Embryonic Stem Cells and Embryonic Germ Cells. The vascular compartment of bone marrow is used to supplied nutrient artery and open into sinuses. The sinus carries the blood from the bone marrow to the body. HSCs have two kinds and include long term stem cells which incorporate transplantation of a new marrow cells to lethally cancerous patients and restore its haemopoietic system for longer periods and short term progenitor which are unable to renew themselves for longer period but immediately regenerate all types of blood cells. The success of been able to inject healthy cells from compatible donor to patients receiving chemotherapy successfully and recipient recover by regaining full functioning healthy blood cells is deemed to have completed stem cells. Large amount of new blood cells are constantly been produced in the blood circulation ensuring steady flow in the peripheral circulation. This type of stem cells is known as pluripotential stem cell (PSC). Pluripotent stem cell however differentiates into other stem cells known as unipotential stem cells: erythropoiesis, monocytes, granulopoiesis, thrombopoiesis and lymphopoiesis are specially multiplied into precursor specifically to individual mature blood cells. Erythropoiesis is the process used to describe red blood cells (erythrocytes) formation exclusively in the red bone marrow involving matured nucleated precursor into erythrocytes. The yellow bone marrow initially composed of fats and subsequently changed to red bone marrow from greater affinity of red blood cells needs. Haemocytoblasts is the precursor of erythrocytes lasting for few days and involved around four mitotic divisions of cells given rise to 8 to 16 more cells. The kidney initiates RBC production in mature cell by responding to lack of oxygen in the blood and secret special hormone called erythropoietin. This hormone is then transferred to red bone marrow and begins production of red blood cell. The RBC fills up the blood capillaries for distribution in the body. After few days the RBC is strong enough to serve oxygen to the body and consequently subsided after few months and loses its affinity to continue oxygen distribution and rupture. The ruptured RBC is then taken up by the spleen for recycled to form new RBC. Monocytes is a type of white blood cells that mature to much larger cells called macrophages and plays major role in immune system of the body that destroy dead cells or tissues damaged and cancer cells. Produced in the bone marrow and develop from nucleated precursors, the monoblast and promonocyte and then goes through the bloodstream for circulation to the spleen, lymph nodes, liver,bone marrow and lungs. Mature cells in monocytes life span is around 3-8 hours with full antigenic stimulation of T and B lymphocytes. Thrombopoiesis is a Platelets formed in the cytoplasm cell called megakaryocyte inside bone marrow with maturity within 10 days from much larger stem cells, megakaryoblast . The platelets formation penetrates into the blood vessels to prevent bleeding, assist clots formation to prevent bleeding and repair damages to blood vessels. Macrophages eventually destroy the platelets in the spleen and liver. Granulopoiesis are formed in the red bone marrow (RBM) called granulocytes and subdivided into three types of white blood cells (WBC); eosinophils, neutrophils and basophils and are grouped in the same stem cells called myeloblast. Granulocytes are produced by the continuous lobulation and condensation of the nucleus, loss of RNA cytoplasmic granules development. A developed cell goes through sinus endothelium where half of the granulocytes circulate to the internal surface of blood vessels and the other half circulates in the blood vessels for exchange. Half of the granulocytes eventually disperse from the circulation in response to requirement in the tissues. Lymphopoieses are precursor to lymphoblasts and prolymphocytes produced in bone marrow. Immature cells are transferred to the lymphoid tissues and thymus, with further division with similar antigens to T cells, B cells and NK cells. They mediate composite and immune effectors. Blood cells (BC) are significant in maintenance of immune system in all types of cells in the body which prompt the BC to constantly maintain self renewal. Haemapoiesis stem cells therefore can proliferate, differentiate and even undergo cell death called apoptosis in various types of specialized cells in the body. The morphology and growth of BC sometimes occurs outside the bone marrow cells called extramedullary haemopoiesis. This is abnormal condition associated with Myelofibrosis caused by disorder in the bone marrow due to abnormal stem cell results or replacement by collagenous connective tissues. The sources of HSC are bone marrow, peripheral blood, umbilical cord blood, Foetal Hematopoietic, Embryonic Stem Cells and Embryonic Germ Cells. The vascular compartment of bone marrow is used to supplied nutrient artery and open into sinuses. The sinus carries the blood from the bone marrow to the body. HSCs have two kinds and include long term stem cells which incorporate transplantation of a new marrow cells to lethally cancerous patients and restore its haemopoietic system for longer periods and short term progenitor which are unable to renew themselves for longer period but immediately regenerate all types of blood cells. The success of been able to inject healthy cells from compatible donor to patients receiving chemotherapy successfully and recipient recover by regaining full functioning healthy blood cells is deemed to have completed stem cells. Leukemia and Lymphoma are some of the cancer of the blood associated with treatment by HSCs. The process relates to the patients defective white blood cells causes by cancer having been destroyed using chemotherapy and replaced with bone marrow transplant matched with donor. Donor are usually from patients family with similar leukocytes antigens. Cancer of the blood are acute or chronic myeloblastics leukemia, multiple myeloma, non-Hodgkins lymphoma and Hodgkins diseases. Name the systems used to classify acute lymphoblastic leukaemia(ALL) and acute myeloid leukaemia (AML). (word limit: 20 words) (2 MARKS) French-American-British (FAB) classification and the World Health Organization (WHO) classifications are two subtypes used in classification of AML and ALL. Define leucocytosis and thrombocytopenia. (word limit: 75 words)(5 MARKS) Leucocytes is a conditions of an abnormal increase of white cells in the blood due to infections. Total white blood cells is approximately 4400 to 11,000 cells/microL. Excess to the value of 50,000/microL, attributed to leukemia is called leukemoid reaction. Thrombocytopenia is a condition where there is abnormal decrease in platelets counts, rendering inability for clot formation resulting in excessive bleeding. Causes can be due to low platelets in bone marrow, intravascular and extravascular. Define leukaemia and state the four main divisions of the disease. (word limit: 70 words) (10 MARKS) Leukaemia is a malignant (cancer) of the bone marrow characterized by uninhibited proliferation of abnormal white blood cells. Symptoms include enlargement of liver, lymph nodes and spleen, anaemia, blood clotting retardation. Four major types of leukaemia are; Acute lymphoblastic leukaemia (ALL) and Chronic lymphocytic leukaemia (CLL) classified as Lymphocytic or lymphoblastic, Acute myeloid leukaemia (AML) and Chronic myeloid leukaemia (CML) classified as Myelogenous leukemia State the typical manifestation of someone presenting with acute leukaemia including the blood film morphology. (word limit: 200 words) (5 MARKS) Most common symptons includes abnormal bruising and bleeding (thrombocytopaenia), anemia, bleeding gums or irregularity in menstrual period and infections. Anaemia and hypermetabolic state are attributed to fatigue, malaise, weight loss, chest pain and tachycardia. Granulocytopenia can progressively lead to potential life threatening bacterial infections. Developing infection frequently in eyes, nose and mouth known as neutropaenia, trace of blood in urine, fine rash dark red spots called purpura. Sign of fever, abnormal heamostasis are mostly common. Patients may sometimes shows lesion in soft tissues, spina dura and cranial representing tumour of leukaemia cells called granulocytic sarcoma or chroma. Periosteal infiltration and bone marrow may initiate joint pain (Arthralgia) in children with ALL. Meningitis causing vomiting, seizure, papilledema and headache is rare. Blood film morphology diagnosis of AML shows presence of more than 20% myeloblasts in blood cell. Cells appear to be smudge with decrease in thrombocytes. Elevated count of leucocytes 135.3 x 109 /L and thrombocytopenia of 26 x 109 /L indicates signs of acute leukaemia. In AML, Auer rods appear smaller in size, absent of granules, lower RBC counts and appear smaller in morphology. Also ALL contains no granules State the typical manifestation of someone with chronic leukaemia including the blood film morphology. (word limit: 200 words) (5 MARKS) (word limit: 230 words) (15 MARKS) Chronic leukaemia from mature cells is a slow progressive symptom that goes unnoticed for months. Disease is normally notice during normal routine blood test. Immediate treatment is not imminent and may involve chemotherapy treatment in tablet from. Two types of chronic leukaemia: Chronic myeloid leukaemia (CML), cancer of the myeloid cells, and chronic lymphocytic leukaemia (CLL), cancer of the lymphocytes. Chronic lymphocytic leukaemia (CLL) is the most common type characterised by an increased number of lymphocytes (WBC). The lymphocytes are unable to perform normal process of responding to infections by producing antibodies needed to destroy bacteria. Symptoms may be tiredness (anaemia) due to lack of RBC, continuous infections due to WBCs healthy shortages in fighting infections, abnormal lymphocytes in lymph glands causing swelling in neck and arm pits or groin, also swelling in spleen, Low platelets in blood leading to bruising or bleeding without injury, weight loss, fevers and night sweat. Test in blood film morphology indicates nuclei appearance is rounded and condensed chromatin. High level of beta-2-macroglobulin protein in the blood indicates advance CLL. Appearance and large amount of lymphocytosis in the blood more than 10,000 lymphocytes/mm ³ of blood shows presence of the disease. Patient with CLL often have low red blood cells and blood platelets in the body. Explain the following techniques and give one example for each, of application in the diagnosis or monitoring of leukaemia: (word limit: 230) (15 marks). Cytochemistry Is the staining methods use to study, identify and localization of various chemical compounds within living cells and activities of acute leukaemia. The most simplify cytochemistry method of diagnosing leukaemia is Myeloperoxidase (MPO) staining which can be completed within minutes. Its main function is to differentiate AML and ALL. Lysosomal enzyme stored azurophilic granules of neutrophils and monocytes. Used in basophils and eosinophils demonstration. A heme pigmentation react to its green colour secretion found in neutrophils. Immunophenotyping Immunophenotyping is use to analyze heterogeneous populations of cells based on the antigens phenotype according to their resemblance of interest. Example is leukocytes from peripheral blood extract from lymph nodes, leukaemia and lymphoma specific to differentiate cancer cells to normal of immune system. Immunophenotyping is used on a daily basis by pathologist from normal biopsies to bone marrow biopsies from various patients. Method mostly used to analyze and sort T-lymphocytes into subsets based on CD antigens is flow cytometry techniques. Samples of cells are analyzed in a multi-well plate with aid of fluorescence or scatter laser light to sort out population by immunophenotypic markers type. Cytogenetics The branch of genetics specialized in the studies of relationships between the structure of cell division and chromosomes relating to variation in phenotype and genotype. Test are carried out in blood samples and bone marrow from leukaemia patients to analyse abnormalities in chromosomal link with certain disease. Fluorescent in situ hybridization (FISH) is one of the methods use in routine analysis of cytogenetic band, molecular cytogenetic and G-Banded chromosomes in leukemia against normal chromosome. What is the Philadelphia chromosome? Give an example of where this is commonly found. (word limit: 120 words) (5 MARKS) Philadelphia chromosome (PH) or Philadelphia translocation is a specific chromosomal abnormality that causes chronic myelogenous leukemia (CML). It is an abnormally chromosome 22 involved in an exchange with chromosome 9 which occur at the site of single bone marrow cell and can also be located in form of acute lymphoblastic leukemia (ALL). The clonal process expands to the leukaemia and was the first major mutant cell found in malignancy which led to the CML cells combination of BCR-ABL gene protein. These genes belong to chromosome 22 and 9 respectively. The activities of both PH chromosome fused together causing uncontrolled malignant in the cell is a strong indication of pathogenic disease. The drug mesylate (Gleevec) was introduced through understanding of this mechanism to aid in cancer treatment. State the difference between stem cell and bone marrow transplants. (word limit: 100 words) (4 MARKS) Stem cell transplantation is a method where the stem cells are obtained from the peripheral blood using aphaeresis method. Aphaeresis assists in stem cells filtrations and avoids unwanted blood. When stem cells are obtained from the outpatient donor from the blood stream, they are less invasive and patient can recover very quickly at home. Stem cell harvested from the bone marrow using fine needle inseted into the hip joint however required critical method from in patient to be hospitalized and put under general aneshesia for continue monitoring. Stem cells collected from the bone marrow are much richer in stems compare with stem collected from the peripheral blood. State the difference between autologous and allogenic transplants. (word limit: 50 words) (4 MARKS) Difference between an autologous transplant is when patients own blood forming cell are collected for use in transplataion later, while an allogenic transplant relies on cells collected from volunteers bone marrow. The donors tissue type must be compatible to the recipient to avoid miss match.

Machines: Are They Helpful Or Too Much Trouble? :: essays research papers

Machines: Are They Helpful Or Too Much Trouble? The historiography and various phases of the Industrial Revolution were very important. Population increase and the expansion of capital, credit and commerce were one of the phases. The role of entrepreneurs, workers and inventions in boosting production were another phase. Textiles, coal, transport and public services started becoming of value to people. The social consequences included women and children working in factories and mines. Hard living conditions, crowded rooms, and many diseases.   Ã‚  Ã‚  Ã‚  Ã‚  There were many positive effects, new inventions, that helped made living comfortable, and saved many lives. A vaccination was created saving many lives, telephones helped people to communicate, light bulbs gave light at night and when rain was falling. As people needed employment, they traveled to London to find work, which caused the population to increase. Developers built multi story building(apartments), and row houses making streets less crowded, and gave the people a newfound wealth and security. Steam engines made it easy to transport goods, the cotton gin made it easier to clean cotton, and made more money. Then technical schools began to develop, helping young people finish grammar school. Women also started working, they were very obedient and men started giving them more respect.   Ã‚  Ã‚  Ã‚  Ã‚  Along with positive, were also negative. Most people worked twelve to fourteen hours a day, six days a week, they had to pay constant attention to the machines and risked losing limbs in the machines. Child labor was another problem, they usually worked from 6 am to 7 p.m., getting paid only 10 percent wages of men to children. They would be severely beaten, and usually was deformed from machines. Many working-class children were not able to attend schools, because they couldn't afford clothes. Women usually spent long hours away from home and were unable to take care of children. They usually had a deformed chest or rib from the machines, and sometimes their hair and long skirt were caught in the machines. Some people had to work in mines, the mines were damp and ark, workers risked suffocation from the dust and drowning from underground floods. As population grew, people moved into urban areas. This was a very big problem, crimes and diseases increased, sometimes twenty families had to share the same toilets and water pumps.   Ã‚  Ã‚  Ã‚  Ã‚  The industrial revolution had many problems, but here are some solutions I would propose.

Bugatti Veyron Essay

The Bugatti Veyron is a mid-engined car. The Super Sport version is the fastest road-legal production car in the world, with a top speed of 431 km/h. The original version has a top speed of 408.00 km/h. Designed and developed by Volkswagen Group and produced by Bugatti Automobiles SAS at their headquarters in Chà ¢teau Saint Jean in Molsheim (Alsace, France), the Veyron’s chief designer was Hartmut Warkuss, and the exterior was designed by Jozef Kabaň of Volkswagen, And much of the engineering work being conducted under the guidance of Bugatti Engineering chief Wolfgang Schreiber. Though commissioned by Volkswagen, this car is only sold through the Bugatti manufacturers and cannot be found at any Volkswagen dealer. The car is named after French racing driver Pierre Veyron, who won the 24 hours of Le Mans in 1939 while racing for the original Bugatti company. The â€Å"16.4† refers to 16 cylinders and 4 turbochargers. The Veyron features an 8.0 litre, quad-turbocharged, W16 cylinder engine, equivalent to two narrow-angle V8 engines . Each cylinder has four valves for a total of sixty four; the engine is fed by four turbochargers. According to Volkswagen Group, the Veyron engine produces 1,001 metric horsepower of motive power, and generates 1,250 N-m of torque while super sport edition produces 1,200 metric horsepower and torque of 1,500 N ·m and has a revised aerodynamic package. The transmission is a dual-clutch direct-shift gearbox ,computer-controlled ,automatic with seven gear ratios and a shift time of less than 150 milliseconds, built by Ricardo of England. The Veyron can be driven in either semi- or fully automatic mode. A replacement transmission for the Veyron costs just over US$120,000. It also has permanent four wheel drive. It uses special Michelin PAX run-flat tyres, designed specifically to accommodate the Veyron’s top speed, which cost US$25,000 per set. The tyres can be removed from the rims only in France, a service which costs US$70,000 The total engine in actual produces 3600 hp of which only 1/3rd is used for running the car and the remaining is in the form of heat. The Bugatti Veyron has a total of ten radiators. Top speed On 4 July 2010, Bugatti’s official test driver Pierre Henri Raphanel piloted the Super Sport edition and was clocked at an average of 431.072 km/h on the Volkswagen Group’s private Ehra-Lessien test track to establish the car’s top speed With representatives of the Guinness Book of Records on hand taking back the title from the SSC Ultimate Aero TT as the fastest production vehicle. All production models will be electronically limited to 415 km/h to protect the tyres. German inspection officials recorded an average top speed of the EB 16.4 version of 408.47 km/h during test sessions on the Ehra-Lessien test track on 19 April 2005. This top speed was verified by James May on Top Gear in November 2006, again at Volkswagen Group’s private Ehra-Lessien test track. When the car reaches 220 km/h, hydraulics lower the car until it has a ground clearance of about 9 cm (3.5 in). At the same time, the wing and spoiler deploy. In this handling mode the wing provides 3,425 Newton’s of down force, holding the car to the road. For top speed mode the driver must, while at rest, toggle a special top speed key to the left of the driver’s seat called as â€Å" second ignition† to unlock limiter of 350km/h.The rear spoiler retracts and angle of rear wing to horizontal is modified into 2 °, the front air diffusers shut, and normal 12.5 cm (4.9 in) ground clearance(i.e. Height from the ground ) drops to 6.5 cm (2.6 in). The Veyron’s brakes use cross drilled, radially vented carbon fibre reinforced silicon carbide (C/SiC) composite discs, manufactured by SGL Carbon, which have a much greater resistance to brake fade when compared with conventional cast iron discs. Bugatti claims maximum deceleration of 12.747 m/s2 on road tyres. At speeds above 200 km/h , the rear wing also acts as an airbrake, snapping to a 55 ° angle in 0.4 seconds once brakes are applied, providing an additional 6.66 m/s2 of deceleration equivalent to the stopping power of an ordinary hatchback. Bugatti claims the Veyron will brake from 400 km/h to a standstill in less than 10 seconds, though distance covered in this time will be half of a kilometre (third of a mile).

The Rise of the Superbugs

A Superbug is a bacterium that can live in the human body and has the ability to withstand all forms of antibiotic medication. Superbugs are becoming increasingly significant in modern medicine as they are becoming more and more resistant to antibiotics. Antibiotics were discovered in 1928 by Alexander Fleming (Walsh and McManus, 2000). This resulted in a huge movement forward in medical history and even greatened human life expectancy. Since then antibiotics have been widely used and abused, people began to treat everything with this ‘miracle’ drug. If antibiotics are continually used as bacteria grows exponentially more resistant to them then eventually society will fall back into an era without the readily use of antibiotics. Fortunately the superbug is not currently immune to all antibiotics as some forms of antibiotics can still treat the bacteria. In years to come the superbug will become increasingly hazardous to mainstream society as it grows faster than scientists can create medication for. Bacteria are the main source for all diseases and deaths worldwide and have been on earth for billions of years, much longer than humans. Bacteria were first discovered by a Dutchman named Anton van Leeuwenhoek in the 1660’s but it wasn’t until the 1850’s that bacteria was regarded as the main cause of disease. Because bacteria have been around for so long it has evolved to adapt to most environments to withstand any other organisms. In the 1930’s Alexander Fleming, Ernst Chain and Howard Florey discovered an antibody which could destroy most bacteria and assist to fight infectious diseases. Many experiments were completed to understand the full impact antibiotics had on humans and how much was needed to rid someone of disease. Drug companies began to mass produce Antibiotics as a means of curing infections and diseases, but only a few years later scientists began to observe the bacteria’s resistance to antibiotics. Like most environments, bacteria were able to adapt to live comfortably with the Antibiotics. Darwin’s theory of evolution states that through natural selection the fittest will survive, this is the case for bacteria living with antibiotics. (Wiley, 2004) ‘The introduction of an antibiotic alters the environment and acts as a selective pressure’. They had developed a resistant by numerous ways, the most common being horizontal gene transmission. This is the passing of genetic material between bacterial cells and can be done by three different processes. The first being Conjugation, which is the transmission of resistant genes through plasmids. Plasmids are small strands within a call which are able to replicate the DNA of a chromosome and carry information around the cell and to other cells. It allows the cell the ability to adapt to different environments. The bacterium achieves antibiotic resistance by direct contact with another bacterium where the plasmid moves into the other cell through a protein tube called a Pilus. The second is Transformation, a cell will pick up DNA from their environment, usually from other dead cells and then incorporate it into its own genetic makeup. The third is called Transduction. This is where bacteriophages, which are small viruses, pass through bacteria injecting themselves inside. When a phage moves to the next bacterium it carries a small amount of the genetic code from the previous cell, allowing the DNA to pass between cells. Wiley, 2004) (Bailey, 2013). These bacteria then split and multiply, creating a bacterium that is resistant to most antibiotics and these are known as superbugs. Superbugs are growing at an exponential rate, with more antibiotics used, bacteria has the perfect environment to create an ideal resistant bacterium. For many years now scientists have known of this increasing issu e, attempting to create new forms of antibiotics while the bacteria will always adapt and grow resistant to. To quote Alexander Fleming: ‘The greatest possibility of evil in self-medication is the use of too small doses so that instead of clearing up infection the microbes are educated to resist penicillin and a host of penicillin-fast organisms is bred out which can be passed to other individuals and from them to others until they reach someone who gets a septicemia or pneumonia which penicillin cannot save. ’ (Walsh and McManus, 2000). The superbug poses a huge threat to society in many ways and it raises many issues. How should the patient be handled? How many different types of antibiotics are too much for a person to retain? How can people living in poverty prevent the spread of bacteria? The rise of the superbug produces numerous questions surrounding the care of patients and the fast spread of the resistant bacteria. The way scientists and doctors treat and care for their patients should be top priority, but when the patient is either living in poverty or in an area with limited resources it becomes difficult. In many poor cultures the superbug is growing much faster because they don’t necessarily have the understanding to prevent the spread of bacteria. In places like India and Pakistan antibiotics can be bought readily at pharmacies without prescriptions. Because many people think antibiotics can cure anything they use them inappropriately, therefore creating an environment for the bacteria to grow resistant. This is a major issue in Southern Asia as the rise of superbugs is much faster here than other countries. Reasons for this include the ease of access to antibiotics, the method of isolation for patients with the superbug and the contamination of water by antibiotics. Many drug companies deposit their waste into rivers nearby, creating the perfect environment for bacteria. Isolation of patients is significant in controlling the outbreak of the superbug but in many Southern Asian countries isolation is not very well managed. Limited resources mean there is limited rooms and limited money and as a result many hospitals provide suitable grounds for the superbug. In many Western countries isolation can also be a problem but in a different way. Because some bacteria can spread so easily, isolation becomes the solution. While they are dying from that disease they are probably going to infect others. So on a public health point of view it’s better off not treating them and sending them off to die alone’ (4 Corners, 2012). Economically many drug companies aren’t developing new ways to defeat the superbug because it’s not as profitable as manufacturing drugs that people will need for their entire lives. As a result there are only a small number of companies attempting to defeat the superbug. Another area for concern is the current rate of antibiotics going into animal feed. In 1998, in the United States, 80 million prescriptions of antibiotics for human use were filled. This equals 12,500 tons in one year. Animal and agricultural uses of antibiotics are added to human use. Agricultural practices account for over 60% of antibiotic usage in the U. S. , so this adds an additional 18,000 tons per year to the antibiotic burden in the environment’ (Kenneth Todar, 2012). Politically this number is far too large to sustain as it is expensive and eventually won’t help the animals, rather it will just create more superbugs. The most important question is what is being done to prevent the rise of superbugs. Scientists develop numerous ways to do this, most failing. But recently there have been a few breakthroughs in terms of stopping the superbugs from killing humans. Firstly, more than ? of all antibiotics used are from soil. Antibiotics are also found hundreds of metres underground in caves, where the living conditions are harsh. In order for the bacteria to survive they must either defend their own resources very well or attack other bacteria, by producing bacteria killing chemicals, to get their resources. Collecting these chemicals could produce a new antibody that is extremely powerful because it has survived in such harsh environments. Secondly, just as bacteria have been on earth for billions of years, so have bacteriophages. A bacteriophage is a virus for bacteria; it injects itself into the bacterium and produces many replicas of itself inside. It will keep replicating until the bacteria splits or bursts. As there are many different types of bacteria there are also any different bacteriophages, which makes it difficult to find the right phage for the bacteria. Using bacteriophages to kill bacteria is better than antibiotics because they have the ability to adapt to their environment. Lastly bacteria can’t kill on it’s own, it must have a large number of bacteria to create any damage to a person. It was discovered quite recently that bacteria have the ability to communicate with each other, they release molecules that grow in proportion to the number of bacteria so when that number gets high enough the receptors on the bacteria communicate and change their behaviour at the same time (SBS Documentary, 2013). This is known as quorum sensing. Being able to stop the communication between bacteria would prevent the bacteria from harming people, they would be inactive. Many scientists have produced other methods to prevent the rise of the superbug but unfortunately most bacteria have evolved and become resistant. Currently there are very little bacteria that have fully evolved to be resistant to all antibiotics but in the years to come antibiotics could become ineffective. In the past antibiotics were overused, they were used to fight diseases that could not be cured with antibiotics which therefore created antibiotic resistant bacteria. Only in recent times have scientists really begun to address this issue as more and more people are developing the superbug with no appropriate cure yet. The rise of the superbug is becoming increasingly dangerous to society and many ethical, economical and health issues must be answered.